BCR-MRVI1 Fusion FISH Probe
The BCR-MRVI1 Fusion FISH Probe is used to confirm a fusion of the BCR and MRVI1 genes. The fusion of the BCR and MRVI1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BCR-MRVI1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-RERE | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-REOR | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-REGO | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-REGR | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-REAQ | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-ORRE | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-OROR | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-ORGO | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-ORAQ | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-GORE | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-GOOR | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-GOGO | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-GOGR | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-GOAQ | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-GRRE | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-GROR | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-GRGO | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-GRGR | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-GRAQ | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-AQRE | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-AQOR | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-AQGO | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-AQGR | 20 (40 μL) | 200 μL |
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| BCR-MRVI1-20-AQAQ | 20 (40 μL) | 200 μL |
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BCR Gene Summary
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: BCR, RhoGEF And GTPase Activating Protein
Chromosome: CHR22: 23522551 -23660224
Locus: 22q11.23
MRVI1 Gene Summary
This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]
Gene Name: Murine Retrovirus Integration Site 1 Homolog
Chromosome: CHR11: 10594637 -10715535
Locus: 11p15.4
Gene Diseases
The BCR MRVI1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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