BCR-HIC2 Fusion FISH Probe
The BCR-HIC2 Fusion FISH Probe is used to confirm a fusion of the BCR and HIC2 genes. The fusion of the BCR and HIC2 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BCR-HIC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-RERE | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-REOR | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-REGO | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-REGR | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-REAQ | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-ORRE | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-OROR | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-ORGO | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-GORE | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-GOOR | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-GOGO | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-GOGR | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-GRRE | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-GROR | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-GRGO | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-GRGR | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-AQRE | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-AQOR | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-AQGO | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-AQGR | 20 (40 μL) | 200 μL |
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| BCR-HIC2-20-AQAQ | 20 (40 μL) | 200 μL |
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BCR Gene Summary
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: BCR, RhoGEF And GTPase Activating Protein
Chromosome: CHR22: 23522551 -23660224
Locus: 22q11.23
HIC2 Gene Summary
The HIC ZBTB Transcriptional Repressor 2 (HIC2) gene is located on chr22 :21771692-21805750 at 22q11.21.
Gene Name: HIC ZBTB Transcriptional Repressor 2
Chromosome: CHR22: 21771692 -21805750
Locus: 22q11.21
Gene Diseases
The BCR HIC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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