BCL7A-WDR66 Fusion FISH Probe
The BCL7A-WDR66 Fusion FISH Probe is used to confirm a fusion of the BCL7A and WDR66 genes. The fusion of the BCL7A and WDR66 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BCL7A-WDR66-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-RERE | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-REOR | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-REGO | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-REGR | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-REAQ | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-ORRE | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-OROR | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-ORGO | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-ORAQ | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-GORE | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-GOOR | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-GOGO | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-GOGR | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-GOAQ | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-GRRE | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-GROR | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-GRGO | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-GRGR | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-GRAQ | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-AQRE | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-AQOR | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-AQGO | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-AQGR | 20 (40 μL) | 200 μL |
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| BCL7A-WDR66-20-AQAQ | 20 (40 μL) | 200 μL |
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BCL7A Gene Summary
This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: BCL Tumor Suppressor 7A
Chromosome: CHR12: 122459860 -122499950
Locus: 12q24.31
WDR66 Gene Summary
This protein encoded by this gene belongs to the WD repeat-containing family of proteins, which function in the formation of protein-protein complexes in a variety of biological pathways. This family member appears to function in the determination of mean platelet volume (MPV), and polymorphisms in this gene have been associated with variance in MPV. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Gene Name: WD Repeat Domain 66
Chromosome: CHR12: 122356462 -122441832
Locus: 12q24.31
Gene Diseases
The BCL7A WDR66 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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