BCL10-DPYD Fusion FISH Probe
The BCL10-DPYD Fusion FISH Probe is used to confirm a fusion of the BCL10 and DPYD genes. The fusion of the BCL10 and DPYD genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BCL10-DPYD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-RERE | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-REOR | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-REGO | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-REGR | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-REAQ | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-ORRE | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-OROR | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-ORGO | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-ORAQ | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-GORE | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-GOOR | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-GOGO | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-GOGR | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-GOAQ | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-GRRE | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-GROR | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-GRGO | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-GRGR | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-GRAQ | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-AQRE | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-AQOR | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-AQGO | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-AQGR | 20 (40 μL) | 200 μL |
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| BCL10-DPYD-20-AQAQ | 20 (40 μL) | 200 μL |
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DPYD Gene Summary
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Name: Dihydropyrimidine Dehydrogenase
Chromosome: CHR1: 97543299 -98386615
Locus: 1p21.3
BCL10 Gene Summary
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Gene Name: B-cell CLL/lymphoma 10
Chromosome: CHR1: 85731459 -85742587
Locus: 1p22.3
Gene Diseases
The BCL10 DPYD Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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