BCKDHB-TTK Fusion FISH Probe
The BCKDHB-TTK Fusion FISH Probe is used to confirm a fusion of the BCKDHB and TTK genes. The fusion of the BCKDHB and TTK genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BCKDHB-TTK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-RERE | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-REOR | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-REGO | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-REGR | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-REAQ | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-ORRE | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-OROR | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-ORGO | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-ORAQ | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-GORE | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-GOOR | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-GOGO | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-GOGR | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-GOAQ | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-GRRE | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-GROR | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-GRGO | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-GRGR | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-GRAQ | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-AQRE | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-AQOR | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-AQGO | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-AQGR | 20 (40 μL) | 200 μL |
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| BCKDHB-TTK-20-AQAQ | 20 (40 μL) | 200 μL |
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BCKDHB Gene Summary
This gene encodes the E1 beta subunit of branched-chain keto acid dehydrogenase, which is a multienzyme complex associated with the inner membrane of mitochondria. This enzyme complex functions in the catabolism of branched-chain amino acids. Mutations in this gene have been associated with maple syrup urine disease (MSUD), type 1B, a disease characterized by a maple syrup odor to the urine in addition to mental and physical retardation and feeding problems. Alternative splicing at this locus results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: Branched Chain Keto Acid Dehydrogenase E1 Subunit Beta
Chromosome: CHR6: 80816343 -81055987
Locus: 6q14.1
TTK Gene Summary
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Gene Name: TTK Protein Kinase
Chromosome: CHR6: 80714321 -80752244
Locus: 6q14.1
Gene Diseases
The BCKDHB TTK Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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