BCKDHB-ME1 Fusion FISH Probe
The BCKDHB-ME1 Fusion FISH Probe is used to confirm a fusion of the BCKDHB and ME1 genes. The fusion of the BCKDHB and ME1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BCKDHB-ME1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-RERE | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-REOR | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-REGO | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-REGR | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-REAQ | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-ORRE | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-OROR | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-ORGO | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-ORAQ | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-GORE | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-GOOR | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-GOGO | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-GOGR | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-GOAQ | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-GRRE | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-GROR | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-GRGO | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-GRGR | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-GRAQ | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-AQRE | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-AQOR | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-AQGO | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-AQGR | 20 (40 μL) | 200 μL |
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| BCKDHB-ME1-20-AQAQ | 20 (40 μL) | 200 μL |
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BCKDHB Gene Summary
This gene encodes the E1 beta subunit of branched-chain keto acid dehydrogenase, which is a multienzyme complex associated with the inner membrane of mitochondria. This enzyme complex functions in the catabolism of branched-chain amino acids. Mutations in this gene have been associated with maple syrup urine disease (MSUD), type 1B, a disease characterized by a maple syrup odor to the urine in addition to mental and physical retardation and feeding problems. Alternative splicing at this locus results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: Branched Chain Keto Acid Dehydrogenase E1 Subunit Beta
Chromosome: CHR6: 80816343 -81055987
Locus: 6q14.1
ME1 Gene Summary
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]
Gene Name: Malic Enzyme 1
Chromosome: CHR6: 83920109 -84140938
Locus: 6q14.2
Gene Diseases
The BCKDHB ME1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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