BCAR3-ABCA4 Fusion FISH Probe
The BCAR3-ABCA4 Fusion FISH Probe is used to confirm a fusion of the BCAR3 and ABCA4 genes. The fusion of the BCAR3 and ABCA4 genes has been associated with Uterine Corpus Endometrial Carcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BCAR3-ABCA4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-RERE | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-REOR | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-REGO | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-REGR | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-REAQ | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-ORRE | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-OROR | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-ORGO | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-ORAQ | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-GORE | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-GOOR | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-GOGO | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-GOGR | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-GOAQ | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-GRRE | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-GROR | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-GRGO | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-GRGR | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-GRAQ | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-AQRE | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-AQOR | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-AQGO | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-AQGR | 20 (40 μL) | 200 μL |
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| BCAR3-ABCA4-20-AQAQ | 20 (40 μL) | 200 μL |
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ABCA4 Gene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2. [provided by RefSeq, Jul 2008]
Gene Name: ATP Binding Cassette Subfamily A Member 4
Chromosome: CHR1: 94458393 -94586705
Locus: 1p22.1
BCAR3 Gene Summary
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Name: BCAR3, NSP Family Adaptor Protein
Chromosome: CHR1: 94027348 -94147385
Locus: 1p22.1
Gene Diseases
The BCAR3 ABCA4 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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