BCAM-PLAT Fusion FISH Probe
The BCAM-PLAT Fusion FISH Probe is used to confirm a fusion of the BCAM and PLAT genes. The fusion of the BCAM and PLAT genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BCAM-PLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-RERE | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-REOR | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-REGO | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-REGR | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-REAQ | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-ORRE | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-OROR | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-ORGO | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-GORE | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-GOOR | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-GOGO | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-GOGR | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-GRRE | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-GROR | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-GRGO | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-GRGR | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-AQRE | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-AQOR | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-AQGO | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-AQGR | 20 (40 μL) | 200 μL |
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| BCAM-PLAT-20-AQAQ | 20 (40 μL) | 200 μL |
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BCAM Gene Summary
This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Name: Basal Cell Adhesion Molecule (Lutheran Blood Group)
Chromosome: CHR19: 45312337 -45324678
Locus: 19q13.32
PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
Gene Diseases
The BCAM PLAT Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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