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BBX-RB1 Fusion FISH Probe

The BBX-RB1 Fusion FISH Probe is used to confirm a fusion of the BBX and RB1 genes. The fusion of the BBX and RB1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
BBX-RB1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
BBX-RB1-20-RERE 20 (40 μL) 200 μL
BBX-RB1-20-REOR 20 (40 μL) 200 μL
BBX-RB1-20-REGO 20 (40 μL) 200 μL
BBX-RB1-20-REGR 20 (40 μL) 200 μL
BBX-RB1-20-REAQ 20 (40 μL) 200 μL
BBX-RB1-20-ORRE 20 (40 μL) 200 μL
BBX-RB1-20-OROR 20 (40 μL) 200 μL
BBX-RB1-20-ORGO 20 (40 μL) 200 μL
BBX-RB1-20-ORAQ 20 (40 μL) 200 μL
BBX-RB1-20-GORE 20 (40 μL) 200 μL
BBX-RB1-20-GOOR 20 (40 μL) 200 μL
BBX-RB1-20-GOGO 20 (40 μL) 200 μL
BBX-RB1-20-GOGR 20 (40 μL) 200 μL
BBX-RB1-20-GOAQ 20 (40 μL) 200 μL
BBX-RB1-20-GRRE 20 (40 μL) 200 μL
BBX-RB1-20-GROR 20 (40 μL) 200 μL
BBX-RB1-20-GRGO 20 (40 μL) 200 μL
BBX-RB1-20-GRGR 20 (40 μL) 200 μL
BBX-RB1-20-GRAQ 20 (40 μL) 200 μL
BBX-RB1-20-AQRE 20 (40 μL) 200 μL
BBX-RB1-20-AQOR 20 (40 μL) 200 μL
BBX-RB1-20-AQGO 20 (40 μL) 200 μL
BBX-RB1-20-AQGR 20 (40 μL) 200 μL
BBX-RB1-20-AQAQ 20 (40 μL) 200 μL

RB1 Gene Summary

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

Gene Name: RB Transcriptional Corepressor 1

Chromosome: CHR13: 48877882 -49056026

Locus: 13q14.2

BBX Gene Summary

The BBX, HMG-box Containing (BBX) gene is located on chr3 :107241782-107530049 at 3q13.12.

Gene Name: BBX, HMG-box Containing

Chromosome: CHR3: 107241782 -107530049

Locus: 3q13.12

Gene Diseases

The BBX RB1 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

The Utility of ERBB4 and RB1 Immunohistochemistry in Distinguishing Chromophobe Renal Cell Carcinoma From Renal Oncocytoma

Renal oncocytoma (RO) is a benign epithelial neoplasm that makes up about 5 to 9% of all renal cell tumors. RO can be difficult to distinguish from a closely related but malignant counterpart, chromophobe renal cell carcinoma (ChrCC). This study used both IHC and FISH to detect the presence of RB1 and ERBB4, two genes that have been found deleted in ChrCC but not RO. A total of 28 ChrCCs and 25 RO cases were tested. Empire Genomics’ RB1 and ERBB4 FISH probes were used to detect deletions in these genes.