BAX-VAV2 Fusion FISH Probe
The BAX-VAV2 Fusion FISH Probe is used to confirm a fusion of the BAX and VAV2 genes. The fusion of the BAX and VAV2 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BAX-VAV2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-RERE | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-REOR | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-REGO | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-REGR | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-REAQ | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-ORRE | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-OROR | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-ORGO | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-ORAQ | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-GORE | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-GOOR | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-GOGO | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-GOGR | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-GOAQ | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-GRRE | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-GROR | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-GRGO | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-GRGR | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-GRAQ | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-AQRE | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-AQOR | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-AQGO | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-AQGR | 20 (40 μL) | 200 μL |
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| BAX-VAV2-20-AQAQ | 20 (40 μL) | 200 μL |
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BAX Gene Summary
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]
Gene Name: BCL2 Associated X, Apoptosis Regulator
Chromosome: CHR19: 49458116 -49465055
Locus: 19q13.33
VAV2 Gene Summary
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Name: Vav Guanine Nucleotide Exchange Factor 2
Chromosome: CHR9: 136627015 -136857446
Locus: 9q34.2
Gene Diseases
The BAX VAV2 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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