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BAG4-ZMAT4 Fusion FISH Probe

The BAG4-ZMAT4 Fusion FISH Probe is used to confirm a fusion of the BAG4 and ZMAT4 genes. The fusion of the BAG4 and ZMAT4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
BAG4-ZMAT4-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
BAG4-ZMAT4-20-RERE 20 (40 μL) 200 μL
BAG4-ZMAT4-20-REOR 20 (40 μL) 200 μL
BAG4-ZMAT4-20-REGO 20 (40 μL) 200 μL
BAG4-ZMAT4-20-REGR 20 (40 μL) 200 μL
BAG4-ZMAT4-20-REAQ 20 (40 μL) 200 μL
BAG4-ZMAT4-20-ORRE 20 (40 μL) 200 μL
BAG4-ZMAT4-20-OROR 20 (40 μL) 200 μL
BAG4-ZMAT4-20-ORGO 20 (40 μL) 200 μL
BAG4-ZMAT4-20-ORAQ 20 (40 μL) 200 μL
BAG4-ZMAT4-20-GORE 20 (40 μL) 200 μL
BAG4-ZMAT4-20-GOOR 20 (40 μL) 200 μL
BAG4-ZMAT4-20-GOGO 20 (40 μL) 200 μL
BAG4-ZMAT4-20-GOGR 20 (40 μL) 200 μL
BAG4-ZMAT4-20-GOAQ 20 (40 μL) 200 μL
BAG4-ZMAT4-20-GRRE 20 (40 μL) 200 μL
BAG4-ZMAT4-20-GROR 20 (40 μL) 200 μL
BAG4-ZMAT4-20-GRGO 20 (40 μL) 200 μL
BAG4-ZMAT4-20-GRGR 20 (40 μL) 200 μL
BAG4-ZMAT4-20-GRAQ 20 (40 μL) 200 μL
BAG4-ZMAT4-20-AQRE 20 (40 μL) 200 μL
BAG4-ZMAT4-20-AQOR 20 (40 μL) 200 μL
BAG4-ZMAT4-20-AQGO 20 (40 μL) 200 μL
BAG4-ZMAT4-20-AQGR 20 (40 μL) 200 μL
BAG4-ZMAT4-20-AQAQ 20 (40 μL) 200 μL

BAG4 Gene Summary

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Gene Name: BCL2 Associated Athanogene 4

Chromosome: CHR8: 38034105 -38070819

Locus: 8p11.23

ZMAT4 Gene Summary

The Zinc Finger Matrin-type 4 (ZMAT4) gene is located on chr8 :40388110-40755343 at 8p11.21.

Gene Name: Zinc Finger Matrin-type 4

Chromosome: CHR8: 40388110 -40755343

Locus: 8p11.21

Gene Diseases

The BAG4 ZMAT4 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.