BAG4-WRN Fusion FISH Probe
The BAG4-WRN Fusion FISH Probe is used to confirm a fusion of the BAG4 and WRN genes. The fusion of the BAG4 and WRN genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BAG4-WRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-RERE | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-REOR | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-REGO | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-REGR | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-REAQ | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-ORRE | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-OROR | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-ORGO | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-GORE | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-GOOR | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-GOGO | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-GOGR | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-GRRE | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-GROR | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-GRGO | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-GRGR | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-AQRE | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-AQOR | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-AQGO | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-AQGR | 20 (40 μL) | 200 μL |
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| BAG4-WRN-20-AQAQ | 20 (40 μL) | 200 μL |
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WRN Gene Summary
This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]
Gene Name: Werner Syndrome RecQ Like Helicase
Chromosome: CHR8: 30890777 -31031277
Locus: 8p12
BAG4 Gene Summary
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Gene Name: BCL2 Associated Athanogene 4
Chromosome: CHR8: 38034105 -38070819
Locus: 8p11.23
Gene Diseases
The BAG4 WRN Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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