BAG4-NEDD8 Fusion FISH Probe
The BAG4-NEDD8 Fusion FISH Probe is used to confirm a fusion of the BAG4 and NEDD8 genes. The fusion of the BAG4 and NEDD8 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BAG4-NEDD8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-RERE | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-REOR | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-REGO | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-REGR | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-REAQ | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-ORRE | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-OROR | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-ORGO | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-ORAQ | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-GORE | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-GOOR | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-GOGO | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-GOGR | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-GOAQ | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-GRRE | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-GROR | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-GRGO | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-GRGR | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-GRAQ | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-AQRE | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-AQOR | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-AQGO | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-AQGR | 20 (40 μL) | 200 μL |
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| BAG4-NEDD8-20-AQAQ | 20 (40 μL) | 200 μL |
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NEDD8 Gene Summary
The Neural Precursor Cell Expressed, Developmentally Down-regulated 8 (NEDD8) gene is located on chr14 :24686056-24701576 at 14q12.
Gene Name: Neural Precursor Cell Expressed, Developmentally Down-regulated 8
Chromosome: CHR14: 24686056 -24701576
Locus: 14q12
BAG4 Gene Summary
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Gene Name: BCL2 Associated Athanogene 4
Chromosome: CHR8: 38034105 -38070819
Locus: 8p11.23
Gene Diseases
The BAG4 NEDD8 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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