BAG4-FGFR1 Fusion FISH Probe
The BAG4-FGFR1 Fusion FISH Probe is used to confirm a fusion of the BAG4 and FGFR1 genes. The fusion of the BAG4 and FGFR1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BAG4-FGFR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-RERE | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-REOR | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-REGO | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-REGR | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-REAQ | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-ORRE | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-OROR | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-ORGO | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-GORE | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-GOOR | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-GOGO | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-GOGR | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-GRRE | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-GROR | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-GRGO | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-GRGR | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-AQRE | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-AQOR | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-AQGO | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-AQGR | 20 (40 μL) | 200 μL |
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| BAG4-FGFR1-20-AQAQ | 20 (40 μL) | 200 μL |
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FGFR1 Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Gene Name: Fibroblast Growth Factor Receptor 1
Chromosome: CHR8: 38268655 -38326352
Locus: 8p11.23
BAG4 Gene Summary
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Gene Name: BCL2 Associated Athanogene 4
Chromosome: CHR8: 38034105 -38070819
Locus: 8p11.23
Gene Diseases
The BAG4 FGFR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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