BAG2-ZNF451 Fusion FISH Probe
The BAG2-ZNF451 Fusion FISH Probe is used to confirm a fusion of the BAG2 and ZNF451 genes. The fusion of the BAG2 and ZNF451 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BAG2-ZNF451-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-RERE | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-REOR | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-REGO | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-REGR | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-REAQ | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-ORRE | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-OROR | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-ORGO | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-ORAQ | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-GORE | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-GOOR | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-GOGO | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-GOGR | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-GOAQ | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-GRRE | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-GROR | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-GRGO | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-GRGR | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-GRAQ | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-AQRE | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-AQOR | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-AQGO | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-AQGR | 20 (40 μL) | 200 μL |
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| BAG2-ZNF451-20-AQAQ | 20 (40 μL) | 200 μL |
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BAG2 Gene Summary
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Gene Name: BCL2 Associated Athanogene 2
Chromosome: CHR6: 57037103 -57050012
Locus: 6p12.1
ZNF451 Gene Summary
The Zinc Finger Protein 451 (ZNF451) gene is located on chr6 :56954827-57035098 at 6p12.1.
Gene Name: Zinc Finger Protein 451
Chromosome: CHR6: 56954827 -57035098
Locus: 6p12.1
Gene Diseases
The BAG2 ZNF451 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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