BACH1-DSCR3 Fusion FISH Probe
The BACH1-DSCR3 Fusion FISH Probe is used to confirm a fusion of the BACH1 and DSCR3 genes. The fusion of the BACH1 and DSCR3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BACH1-DSCR3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-RERE | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-REOR | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-REGO | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-REGR | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-REAQ | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-ORRE | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-OROR | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-ORGO | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-ORAQ | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-GORE | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-GOOR | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-GOGO | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-GOGR | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-GOAQ | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-GRRE | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-GROR | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-GRGO | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-GRGR | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-GRAQ | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-AQRE | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-AQOR | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-AQGO | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-AQGR | 20 (40 μL) | 200 μL |
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| BACH1-DSCR3-20-AQAQ | 20 (40 μL) | 200 μL |
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BACH1 Gene Summary
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]
Gene Name: BTB Domain And CNC Homolog 1
Chromosome: CHR21: 30677559 -30734217
Locus: 21q21.3
DSCR3 Gene Summary
The region of chromosome 21 between genes CBR and ERG (CBR-ERG region), which spans 2.5 Mb on 21q22.2, has been defined by analysis of patients with partial trisomy 21. It contributes significantly to the pathogenesis of many characteristics of Down syndrome, including morphological features, hypotonia, and cognitive disability. The DSCR3 (Down syndrome critical region gene 3) gene is found in this region and is predictated to contain eight exons. DSCR3 is expressed in most tissues examined. [provided by RefSeq, Jul 2008]
Gene Name: DSCR3 Arrestin Fold Containing
Chromosome: CHR21: 38595725 -38639833
Locus: 21q22.13
Gene Diseases
The BACH1 DSCR3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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