B4GALT7-NSD1 Fusion FISH Probe
The B4GALT7-NSD1 Fusion FISH Probe is used to confirm a fusion of the B4GALT7 and NSD1 genes. The fusion of the B4GALT7 and NSD1 genes has been associated with Breast Invasive Carcinoma, and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| B4GALT7-NSD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-RERE | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-REOR | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-REGO | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-REGR | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-REAQ | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-ORRE | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-OROR | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-ORGO | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-GORE | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-GOOR | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-GOGO | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-GOGR | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-GRRE | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-GROR | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-GRGO | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-GRGR | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-AQRE | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-AQOR | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-AQGO | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-AQGR | 20 (40 μL) | 200 μL |
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| B4GALT7-NSD1-20-AQAQ | 20 (40 μL) | 200 μL |
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B4GALT7 Gene Summary
This gene is a member of the beta-1,4-galactosyltransferase (beta4GalT) family. Family members encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose. Each beta4GalT member has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus which then remains uncleaved to function as a transmembrane anchor. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein linkage (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) found in proteoglycans. This enzyme differs from other beta4GalTs because it lacks the conserved Cys residues found in beta4GalT1-beta4GalT6 and it is located in cis-Golgi instead of trans-Golgi. Mutations in this gene have been associated with the progeroid form of Ehlers-Danlos syndrome. [provided by RefSeq, Oct 2009]
Gene Name: Beta-1,4-galactosyltransferase 7
Chromosome: CHR5: 177027118 -177037346
Locus: 5q35.3
NSD1 Gene Summary
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Receptor Binding SET Domain Protein 1
Chromosome: CHR5: 176560079 -176727214
Locus: 5q35.3
Gene Diseases
The B4GALT7 NSD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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