B4GALT4-CBLB Fusion FISH Probe
The B4GALT4-CBLB Fusion FISH Probe is used to confirm a fusion of the B4GALT4 and CBLB genes. The fusion of the B4GALT4 and CBLB genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| B4GALT4-CBLB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-RERE | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-REOR | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-REGO | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-REGR | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-REAQ | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-ORRE | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-OROR | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-ORGO | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-ORAQ | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-GORE | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-GOOR | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-GOGO | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-GOGR | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-GOAQ | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-GRRE | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-GROR | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-GRGO | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-GRGR | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-GRAQ | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-AQRE | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-AQOR | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-AQGO | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-AQGR | 20 (40 μL) | 200 μL |
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| B4GALT4-CBLB-20-AQAQ | 20 (40 μL) | 200 μL |
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CBLB Gene Summary
This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]
Gene Name: Cbl Proto-oncogene B
Chromosome: CHR3: 105377108 -105587887
Locus: 3q13.11
B4GALT4 Gene Summary
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Beta-1,4-galactosyltransferase 4
Chromosome: CHR3: 118930588 -118959752
Locus: 3q13.32
Gene Diseases
The B4GALT4 CBLB Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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