B4GALT4-ACSL5 Fusion FISH Probe
The B4GALT4-ACSL5 Fusion FISH Probe is used to confirm a fusion of the B4GALT4 and ACSL5 genes. The fusion of the B4GALT4 and ACSL5 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| B4GALT4-ACSL5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-RERE | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-REOR | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-REGO | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-REGR | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-REAQ | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-ORRE | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-OROR | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-ORGO | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-ORAQ | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-GORE | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-GOOR | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-GOGO | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-GOGR | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-GOAQ | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-GRRE | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-GROR | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-GRGO | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-GRGR | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-GRAQ | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-AQRE | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-AQOR | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-AQGO | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-AQGR | 20 (40 μL) | 200 μL |
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| B4GALT4-ACSL5-20-AQAQ | 20 (40 μL) | 200 μL |
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B4GALT4 Gene Summary
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Beta-1,4-galactosyltransferase 4
Chromosome: CHR3: 118930588 -118959752
Locus: 3q13.32
ACSL5 Gene Summary
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Acyl-CoA Synthetase Long Chain Family Member 5
Chromosome: CHR10: 114133915 -114188138
Locus: 10q25.2
Gene Diseases
The B4GALT4 ACSL5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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