B4GALT1-BAG1 Fusion FISH Probe
The B4GALT1-BAG1 Fusion FISH Probe is used to confirm a fusion of the B4GALT1 and BAG1 genes. The fusion of the B4GALT1 and BAG1 genes has been associated with Lung Adenocarcinoma, Liver Hepatocellular Carcinoma, Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma, and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| B4GALT1-BAG1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-RERE | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-REOR | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-REGO | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-REGR | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-REAQ | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-ORRE | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-OROR | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-ORGO | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-ORAQ | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-GORE | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-GOOR | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-GOGO | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-GOGR | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-GOAQ | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-GRRE | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-GROR | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-GRGO | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-GRGR | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-GRAQ | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-AQRE | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-AQOR | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-AQGO | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-AQGR | 20 (40 μL) | 200 μL |
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| B4GALT1-BAG1-20-AQAQ | 20 (40 μL) | 200 μL |
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BAG1 Gene Summary
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]
Gene Name: BCL2 Associated Athanogene 1
Chromosome: CHR9: 33252469 -33264759
Locus: 9p13.3
B4GALT1 Gene Summary
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase. [provided by RefSeq, Jul 2008]
Gene Name: Beta-1,4-galactosyltransferase 1
Chromosome: CHR9: 33110638 -33167356
Locus: 9p21.1
Gene Diseases
The B4GALT1 BAG1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Liver Hepatocellular Carcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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