AZIN1-ZFPM2 Fusion FISH Probe
The AZIN1-ZFPM2 Fusion FISH Probe is used to confirm a fusion of the AZIN1 and ZFPM2 genes. The fusion of the AZIN1 and ZFPM2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AZIN1-ZFPM2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-RERE | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-REOR | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-REGO | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-REGR | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-REAQ | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-ORRE | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-OROR | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-ORGO | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-ORAQ | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-GORE | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-GOOR | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-GOGO | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-GOGR | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-GOAQ | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-GRRE | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-GROR | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-GRGO | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-GRGR | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-GRAQ | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-AQRE | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-AQOR | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-AQGO | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-AQGR | 20 (40 μL) | 200 μL |
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| AZIN1-ZFPM2-20-AQAQ | 20 (40 μL) | 200 μL |
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ZFPM2 Gene Summary
The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008]
Gene Name: Zinc Finger Protein, FOG Family Member 2
Chromosome: CHR8: 106331146 -106816767
Locus: 8q23.1
AZIN1 Gene Summary
The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]
Gene Name: Antizyme Inhibitor 1
Chromosome: CHR8: 103838535 -103876397
Locus: 8q22.3
Gene Diseases
The AZIN1 ZFPM2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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