AXL-SQSTM1 Fusion FISH Probe
The AXL-SQSTM1 Fusion FISH Probe is used to confirm a fusion of the AXL and SQSTM1 genes. The fusion of the AXL and SQSTM1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AXL-SQSTM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-RERE | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-REOR | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-REGO | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-REGR | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-REAQ | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-ORRE | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-OROR | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-ORGO | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-GORE | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-GOOR | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-GOGO | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-GOGR | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-GRRE | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-GROR | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-GRGO | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-GRGR | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-AQRE | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-AQOR | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-AQGO | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-AQGR | 20 (40 μL) | 200 μL |
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| AXL-SQSTM1-20-AQAQ | 20 (40 μL) | 200 μL |
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AXL Gene Summary
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Gene Name: AXL Receptor Tyrosine Kinase
Chromosome: CHR19: 41725107 -41767671
Locus: 19q13.2
SQSTM1 Gene Summary
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
Gene Name: Sequestosome 1
Chromosome: CHR5: 179233387 -179265077
Locus: 5q35.3
Gene Diseases
The AXL SQSTM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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