AXIN1-TMEM8A Fusion FISH Probe
The AXIN1-TMEM8A Fusion FISH Probe is used to confirm a fusion of the AXIN1 and TMEM8A genes. The fusion of the AXIN1 and TMEM8A genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AXIN1-TMEM8A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-RERE | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-REOR | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-REGO | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-REGR | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-REAQ | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-ORRE | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-OROR | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-ORGO | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-ORAQ | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-GORE | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-GOOR | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-GOGO | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-GOGR | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-GOAQ | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-GRRE | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-GROR | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-GRGO | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-GRGR | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-GRAQ | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-AQRE | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-AQOR | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-AQGO | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-AQGR | 20 (40 μL) | 200 μL |
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| AXIN1-TMEM8A-20-AQAQ | 20 (40 μL) | 200 μL |
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AXIN1 Gene Summary
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: Axin 1
Chromosome: CHR16: 337439 -402676
Locus: 16p13.3
TMEM8A Gene Summary
The Transmembrane Protein 8A (TMEM8A) gene is located on chr16 :420775-431950 at 16p13.3.
Gene Name: Transmembrane Protein 8A
Chromosome: CHR16: 420775 -431950
Locus: 16p13.3
Gene Diseases
The AXIN1 TMEM8A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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