AXIN1-IFT140 Fusion FISH Probe
The AXIN1-IFT140 Fusion FISH Probe is used to confirm a fusion of the AXIN1 and IFT140 genes. The fusion of the AXIN1 and IFT140 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AXIN1-IFT140-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-RERE | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-REOR | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-REGO | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-REGR | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-REAQ | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-ORRE | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-OROR | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-ORGO | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-ORAQ | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-GORE | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-GOOR | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-GOGO | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-GOGR | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-GOAQ | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-GRRE | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-GROR | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-GRGO | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-GRGR | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-GRAQ | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-AQRE | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-AQOR | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-AQGO | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-AQGR | 20 (40 μL) | 200 μL |
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| AXIN1-IFT140-20-AQAQ | 20 (40 μL) | 200 μL |
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AXIN1 Gene Summary
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: Axin 1
Chromosome: CHR16: 337439 -402676
Locus: 16p13.3
IFT140 Gene Summary
This gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based sensory organelle at the surface of most quiescent mammalian cells, that receives signals from its environment, such as the flow of fluid, light or odors, and transduces those signals to the nucleus. Loss of the corresponding protein in mouse results in renal cystic disease. [provided by RefSeq, Jun 2012]
Gene Name: Intraflagellar Transport 140
Chromosome: CHR16: 1560427 -1662109
Locus: 16p13.3
Gene Diseases
The AXIN1 IFT140 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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