AURKA-PCK1 Fusion FISH Probe
The AURKA-PCK1 Fusion FISH Probe is used to confirm a fusion of the AURKA and PCK1 genes. The fusion of the AURKA and PCK1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AURKA-PCK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-RERE | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-REOR | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-REGO | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-REGR | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-REAQ | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-ORRE | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-OROR | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-ORGO | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-GORE | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-GOOR | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-GOGO | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-GOGR | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-GRRE | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-GROR | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-GRGO | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-GRGR | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-AQRE | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-AQOR | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-AQGO | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-AQGR | 20 (40 μL) | 200 μL |
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| AURKA-PCK1-20-AQAQ | 20 (40 μL) | 200 μL |
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PCK1 Gene Summary
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Phosphoenolpyruvate Carboxykinase 1
Chromosome: CHR20: 56136136 -56141513
Locus: 20q13.31
AURKA Gene Summary
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Aurora Kinase A
Chromosome: CHR20: 54944444 -54967351
Locus: 20q13.2
Gene Diseases
The AURKA PCK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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