AUH-CPM Fusion FISH Probe
The AUH-CPM Fusion FISH Probe is used to confirm a fusion of the AUH and CPM genes. The fusion of the AUH and CPM genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AUH-CPM-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-RERE | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-REOR | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-REGO | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-REGR | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-REAQ | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-ORRE | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-OROR | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-ORGO | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-ORAQ | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-GORE | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-GOOR | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-GOGO | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-GOGR | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-GOAQ | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-GRRE | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-GROR | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-GRGO | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-GRGR | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-GRAQ | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-AQRE | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-AQOR | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-AQGO | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-AQGR | 20 (40 μL) | 200 μL |
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| AUH-CPM-20-AQAQ | 20 (40 μL) | 200 μL |
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AUH Gene Summary
This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Gene Name: AU RNA Binding Methylglutaconyl-CoA Hydratase
Chromosome: CHR9: 93976096 -94124206
Locus: 9q22.31
CPM Gene Summary
The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Carboxypeptidase M
Chromosome: CHR12: 69244955 -69357020
Locus: 12q15
Gene Diseases
The AUH CPM Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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