ATXN7-SLC25A26 Fusion FISH Probe
The ATXN7-SLC25A26 Fusion FISH Probe is used to confirm a fusion of the ATXN7 and SLC25A26 genes. The fusion of the ATXN7 and SLC25A26 genes has been associated with Skin Cutaneous Melanoma, and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATXN7-SLC25A26-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-RERE | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-REOR | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-REGO | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-REGR | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-REAQ | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-ORRE | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-OROR | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-ORGO | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-GORE | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-GOOR | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-GOGO | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-GOGR | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-GRRE | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-GROR | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-GRGO | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-GRGR | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-AQRE | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-AQOR | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-AQGO | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-AQGR | 20 (40 μL) | 200 μL |
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| ATXN7-SLC25A26-20-AQAQ | 20 (40 μL) | 200 μL |
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ATXN7 Gene Summary
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 37-306 CAG repeats (near the N-terminus), compared to 4-35 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
Gene Name: Ataxin 7
Chromosome: CHR3: 63850232 -63989136
Locus: 3p14.1
SLC25A26 Gene Summary
This gene is a member of the mitochondrial carrier family which includes nuclear-encoded transporters localized on the inner mitochondrial membranes. Members of the family transport important small molecules across the mitochondrial inner membrane. This protein is involved in the transport of S-adenosylmethionine (SAM) into the mitochondria. Mutations in this gene are associated with combined oxidative phosphorylation deficiency 28. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2017]
Gene Name: Solute Carrier Family 25 Member 26
Chromosome: CHR3: 66119284 -66429351
Locus: 3p14.1
Gene Diseases
The ATXN7 SLC25A26 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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