ATXN2-TRIM37 Fusion FISH Probe
The ATXN2-TRIM37 Fusion FISH Probe is used to confirm a fusion of the ATXN2 and TRIM37 genes. The fusion of the ATXN2 and TRIM37 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATXN2-TRIM37-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-RERE | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-REOR | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-REGO | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-REGR | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-REAQ | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-ORRE | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-OROR | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-ORGO | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-GORE | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-GOOR | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-GOGO | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-GOGR | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-GRRE | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-GROR | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-GRGO | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-GRGR | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-AQRE | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-AQOR | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-AQGO | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-AQGR | 20 (40 μL) | 200 μL |
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| ATXN2-TRIM37-20-AQAQ | 20 (40 μL) | 200 μL |
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TRIM37 Gene Summary
This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. [provided by RefSeq, Mar 2016]
Gene Name: Tripartite Motif Containing 37
Chromosome: CHR17: 57059999 -57184266
Locus: 17q22
ATXN2 Gene Summary
This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticulum and plasma membrane, is involved in endocytosis, and modulates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Gene Name: Ataxin 2
Chromosome: CHR12: 111890017 -112037480
Locus: 12q24.12
Gene Diseases
The ATXN2 TRIM37 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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