ATRX-LPAR4 Fusion FISH Probe
The ATRX-LPAR4 Fusion FISH Probe is used to confirm a fusion of the ATRX and LPAR4 genes. The fusion of the ATRX and LPAR4 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATRX-LPAR4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-RERE | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-REOR | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-REGO | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-REGR | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-REAQ | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-ORRE | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-OROR | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-ORGO | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-GORE | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-GOOR | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-GOGO | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-GOGR | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-GRRE | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-GROR | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-GRGO | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-GRGR | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-AQRE | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-AQOR | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-AQGO | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-AQGR | 20 (40 μL) | 200 μL |
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| ATRX-LPAR4-20-AQAQ | 20 (40 μL) | 200 μL |
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ATRX Gene Summary
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]
Gene Name: ATRX, Chromatin Remodeler
Chromosome: CHRX: 76760355 -77041719
Locus: Xq21.1
LPAR4 Gene Summary
This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009]
Gene Name: Lysophosphatidic Acid Receptor 4
Chromosome: CHRX: 78003205 -78012578
Locus: Xq21.1
Gene Diseases
The ATRX LPAR4 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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