ATRX-ARHGEF9 Fusion FISH Probe
The ATRX-ARHGEF9 Fusion FISH Probe is used to confirm a fusion of the ATRX and ARHGEF9 genes. The fusion of the ATRX and ARHGEF9 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATRX-ARHGEF9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-RERE | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-REOR | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-REGO | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-REGR | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-REAQ | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-ORRE | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-OROR | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-ORGO | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-GORE | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-GOOR | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-GOGO | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-GOGR | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-GRRE | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-GROR | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-GRGO | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-GRGR | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-AQRE | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-AQOR | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-AQGO | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-AQGR | 20 (40 μL) | 200 μL |
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| ATRX-ARHGEF9-20-AQAQ | 20 (40 μL) | 200 μL |
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ATRX Gene Summary
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]
Gene Name: ATRX, Chromatin Remodeler
Chromosome: CHRX: 76760355 -77041719
Locus: Xq21.1
ARHGEF9 Gene Summary
The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. This brain-specific protein also acts as an adaptor protein for the recruitment of gephyrin and together these proteins facilitate receceptor recruitement in GABAnergic and glycinergic synapses. Defects in this gene are the cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy, as well as several other types of cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Gene Name: Cdc42 Guanine Nucleotide Exchange Factor 9
Chromosome: CHRX: 62854847 -63005426
Locus: Xq11.1
Gene Diseases
The ATRX ARHGEF9 Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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