ATR-DBR1 Fusion FISH Probe
The ATR-DBR1 Fusion FISH Probe is used to confirm a fusion of the ATR and DBR1 genes. The fusion of the ATR and DBR1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATR-DBR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-RERE | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-REOR | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-REGO | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-REGR | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-REAQ | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-ORRE | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-OROR | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-ORGO | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-GORE | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-GOOR | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-GOGO | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-GOGR | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-GRRE | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-GROR | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-GRGO | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-GRGR | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-AQRE | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-AQOR | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-AQGO | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-AQGR | 20 (40 μL) | 200 μL |
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| ATR-DBR1-20-AQAQ | 20 (40 μL) | 200 μL |
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ATR Gene Summary
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]
Gene Name: ATR Serine/threonine Kinase
Chromosome: CHR3: 142168076 -142297668
Locus: 3q23
DBR1 Gene Summary
The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011]
Gene Name: Debranching RNA Lariats 1
Chromosome: CHR3: 137879829 -137893791
Locus: 3q22.3
Gene Diseases
The ATR DBR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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