ATP8A1-LDB2 Fusion FISH Probe
The ATP8A1-LDB2 Fusion FISH Probe is used to confirm a fusion of the ATP8A1 and LDB2 genes. The fusion of the ATP8A1 and LDB2 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATP8A1-LDB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-RERE | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-REOR | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-REGO | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-REGR | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-REAQ | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-ORRE | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-OROR | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-ORGO | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-GORE | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-GOOR | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-GOGO | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-GOGR | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-GRRE | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-GROR | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-GRGO | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-GRGR | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-AQRE | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-AQOR | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-AQGO | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-AQGR | 20 (40 μL) | 200 μL |
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| ATP8A1-LDB2-20-AQAQ | 20 (40 μL) | 200 μL |
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LDB2 Gene Summary
The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Gene Name: LIM Domain Binding 2
Chromosome: CHR4: 16503164 -16900424
Locus: 4p15.32
ATP8A1 Gene Summary
The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: ATPase Phospholipid Transporting 8A1
Chromosome: CHR4: 42410391 -42659122
Locus: 4p13
Gene Diseases
The ATP8A1 LDB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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