ATP6V1H-RP1 Fusion FISH Probe
The ATP6V1H-RP1 Fusion FISH Probe is used to confirm a fusion of the ATP6V1H and RP1 genes. The fusion of the ATP6V1H and RP1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATP6V1H-RP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-RERE | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-REOR | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-REGO | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-REGR | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-REAQ | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-ORRE | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-OROR | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-ORGO | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-GORE | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-GOOR | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-GOGO | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-GOGR | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-GRRE | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-GROR | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-GRGO | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-GRGR | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-AQRE | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-AQOR | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-AQGO | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-AQGR | 20 (40 μL) | 200 μL |
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| ATP6V1H-RP1-20-AQAQ | 20 (40 μL) | 200 μL |
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RP1 Gene Summary
This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. Transcript variants resulted from an alternative promoter and alternative splicings have been found, which overlap the current reference sequence and has several exons upstream and downstream of the current reference sequence. However, the biological validity and full-length nature of some variants cannot be determined at this time.[provided by RefSeq, Sep 2010]
Gene Name: RP1, Axonemal Microtubule Associated
Chromosome: CHR8: 55528626 -55543394
Locus: 8q11.23-q12.1
ATP6V1H Gene Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Name: ATPase H+ Transporting V1 Subunit H
Chromosome: CHR8: 54628114 -54755850
Locus: 8q11.23
Gene Diseases
The ATP6V1H RP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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