ATP6V1A-OPA1 Fusion FISH Probe
The ATP6V1A-OPA1 Fusion FISH Probe is used to confirm a fusion of the ATP6V1A and OPA1 genes. The fusion of the ATP6V1A and OPA1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATP6V1A-OPA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-RERE | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-REOR | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-REGO | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-REGR | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-REAQ | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-ORRE | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-OROR | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-ORGO | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-GORE | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-GOOR | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-GOGO | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-GOGR | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-GRRE | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-GROR | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-GRGO | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-GRGR | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-AQRE | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-AQOR | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-AQGO | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-AQGR | 20 (40 μL) | 200 μL |
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| ATP6V1A-OPA1-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP6V1A Gene Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq, Jul 2008]
Gene Name: ATPase H+ Transporting V1 Subunit A
Chromosome: CHR3: 113465865 -113530905
Locus: 3q13.31
OPA1 Gene Summary
The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. [provided by RefSeq, Aug 2017]
Gene Name: OPA1, Mitochondrial Dynamin Like GTPase
Chromosome: CHR3: 193310932 -193415600
Locus: 3q29
Gene Diseases
The ATP6V1A OPA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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