ATP6V0A4-TM4SF20 Fusion FISH Probe
The ATP6V0A4-TM4SF20 Fusion FISH Probe is used to confirm a fusion of the ATP6V0A4 and TM4SF20 genes. The fusion of the ATP6V0A4 and TM4SF20 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATP6V0A4-TM4SF20-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-RERE | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-REOR | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-REGO | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-REGR | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-REAQ | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-ORRE | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-OROR | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-ORGO | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-GORE | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-GOOR | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-GOGO | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-GOGR | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-GRRE | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-GROR | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-GRGO | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-GRGR | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-AQRE | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-AQOR | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-AQGO | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-AQGR | 20 (40 μL) | 200 μL |
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| ATP6V0A4-TM4SF20-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP6V0A4 Gene Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing. [provided by RefSeq, Jul 2008]
Gene Name: ATPase H+ Transporting V0 Subunit A4
Chromosome: CHR7: 138391038 -138482941
Locus: 7q34
TM4SF20 Gene Summary
The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Knockout of the homologous gene in mouse results in a neurobehavioral phenotype with suggested enhanced motor coordination. A deletion mutation in the human gene is associated with specific language impairment-5. [provided by RefSeq, Jul 2016]
Gene Name: Transmembrane 4 L Six Family Member 20
Chromosome: CHR2: 228226873 -228244022
Locus: 2q36.3
Gene Diseases
The ATP6V0A4 TM4SF20 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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