ATP6V0A1-STAT5A Fusion FISH Probe
The ATP6V0A1-STAT5A Fusion FISH Probe is used to confirm a fusion of the ATP6V0A1 and STAT5A genes. The fusion of the ATP6V0A1 and STAT5A genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATP6V0A1-STAT5A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-RERE | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-REOR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-REGO | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-REGR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-REAQ | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-ORRE | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-OROR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-ORGO | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-GORE | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-GOOR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-GOGO | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-GOGR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-GRRE | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-GROR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-GRGO | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-GRGR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-AQRE | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-AQOR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-AQGO | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-AQGR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-STAT5A-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP6V0A1 Gene Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: ATPase H+ Transporting V0 Subunit A1
Chromosome: CHR17: 40610861 -40674597
Locus: 17q21.2
STAT5A Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Gene Name: Signal Transducer And Activator Of Transcription 5A
Chromosome: CHR17: 40439564 -40463960
Locus: 17q21.2
Gene Diseases
The ATP6V0A1 STAT5A Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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