ATP6V0A1-ATF6 Fusion FISH Probe
The ATP6V0A1-ATF6 Fusion FISH Probe is used to confirm a fusion of the ATP6V0A1 and ATF6 genes. The fusion of the ATP6V0A1 and ATF6 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATP6V0A1-ATF6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-RERE | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-REOR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-REGO | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-REGR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-REAQ | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-ORRE | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-OROR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-ORGO | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-GORE | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-GOOR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-GOGO | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-GOGR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-GRRE | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-GROR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-GRGO | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-GRGR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-AQRE | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-AQOR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-AQGO | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-AQGR | 20 (40 μL) | 200 μL |
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| ATP6V0A1-ATF6-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP6V0A1 Gene Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: ATPase H+ Transporting V0 Subunit A1
Chromosome: CHR17: 40610861 -40674597
Locus: 17q21.2
ATF6 Gene Summary
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
Gene Name: Activating Transcription Factor 6
Chromosome: CHR1: 161736033 -161933860
Locus: 1q23.3
Gene Diseases
The ATP6V0A1 ATF6 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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