ATP5L-UBE4A Fusion FISH Probe
The ATP5L-UBE4A Fusion FISH Probe is used to confirm a fusion of the ATP5L and UBE4A genes. The fusion of the ATP5L and UBE4A genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATP5L-UBE4A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-RERE | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-REOR | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-REGO | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-REGR | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-REAQ | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-ORRE | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-OROR | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-ORGO | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-GORE | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-GOOR | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-GOGO | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-GOGR | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-GRRE | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-GROR | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-GRGO | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-GRGR | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-AQRE | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-AQOR | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-AQGO | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-AQGR | 20 (40 μL) | 200 μL |
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| ATP5L-UBE4A-20-AQAQ | 20 (40 μL) | 200 μL |
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UBE4A Gene Summary
This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
Gene Name: Ubiquitination Factor E4A
Chromosome: CHR11: 118230295 -118269926
Locus: 11q23.3
ATP5L Gene Summary
Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
Gene Name: ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit G
Chromosome: CHR11: 118272103 -118280562
Locus: 11q23.3
Gene Diseases
The ATP5L UBE4A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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