ATP2B4-PRELP Fusion FISH Probe
The ATP2B4-PRELP Fusion FISH Probe is used to confirm a fusion of the ATP2B4 and PRELP genes. The fusion of the ATP2B4 and PRELP genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATP2B4-PRELP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-RERE | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-REOR | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-REGO | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-REGR | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-REAQ | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-ORRE | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-OROR | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-ORGO | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-GORE | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-GOOR | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-GOGO | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-GOGR | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-GRRE | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-GROR | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-GRGO | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-GRGR | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-AQRE | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-AQOR | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-AQGO | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-AQGR | 20 (40 μL) | 200 μL |
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| ATP2B4-PRELP-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP2B4 Gene Summary
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: ATPase Plasma Membrane Ca2+ Transporting 4
Chromosome: CHR1: 203595914 -203713209
Locus: 1q32.1
PRELP Gene Summary
The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Gene Name: Proline And Arginine Rich End Leucine Rich Repeat Protein
Chromosome: CHR1: 203444882 -203460479
Locus: 1q32.1
Gene Diseases
The ATP2B4 PRELP Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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