ATP2B1-EXOC4 Fusion FISH Probe
The ATP2B1-EXOC4 Fusion FISH Probe is used to confirm a fusion of the ATP2B1 and EXOC4 genes. The fusion of the ATP2B1 and EXOC4 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATP2B1-EXOC4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-RERE | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-REOR | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-REGO | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-REGR | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-REAQ | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-ORRE | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-OROR | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-ORGO | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-GORE | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-GOOR | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-GOGO | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-GOGR | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-GRRE | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-GROR | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-GRGO | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-GRGR | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-AQRE | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-AQOR | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-AQGO | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-AQGR | 20 (40 μL) | 200 μL |
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| ATP2B1-EXOC4-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP2B1 Gene Summary
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: ATPase Plasma Membrane Ca2+ Transporting 1
Chromosome: CHR12: 89981825 -90049844
Locus: 12q21.33
EXOC4 Gene Summary
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Exocyst Complex Component 4
Chromosome: CHR7: 132937822 -133750513
Locus: 7q33
Gene Diseases
The ATP2B1 EXOC4 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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