ATP1B3-RNF7 Fusion FISH Probe
The ATP1B3-RNF7 Fusion FISH Probe is used to confirm a fusion of the ATP1B3 and RNF7 genes. The fusion of the ATP1B3 and RNF7 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATP1B3-RNF7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-RERE | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-REOR | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-REGO | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-REGR | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-REAQ | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-ORRE | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-OROR | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-ORGO | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-GORE | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-GOOR | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-GOGO | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-GOGR | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-GRRE | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-GROR | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-GRGO | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-GRGR | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-AQRE | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-AQOR | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-AQGO | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-AQGR | 20 (40 μL) | 200 μL |
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| ATP1B3-RNF7-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP1B3 Gene Summary
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]
Gene Name: ATPase Na+/K+ Transporting Subunit Beta 3
Chromosome: CHR3: 141595469 -141645382
Locus: 3q23
RNF7 Gene Summary
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Ring Finger Protein 7
Chromosome: CHR3: 141457050 -141465645
Locus: 3q23
Gene Diseases
The ATP1B3 RNF7 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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