ATP1B1-NRG1 Fusion FISH Probe
The ATP1B1-NRG1 Fusion FISH Probe is used to confirm a fusion of the ATP1B1 and NRG1 genes. The fusion of the ATP1B1 and NRG1 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATP1B1-NRG1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-RERE | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-REOR | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-REGO | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-REGR | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-REAQ | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-ORRE | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-OROR | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-ORGO | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-GORE | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-GOOR | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-GOGO | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-GOGR | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-GRRE | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-GROR | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-GRGO | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-GRGR | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-AQRE | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-AQOR | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-AQGO | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-AQGR | 20 (40 μL) | 200 μL |
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| ATP1B1-NRG1-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP1B1 Gene Summary
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]
Gene Name: ATPase Na+/K+ Transporting Subunit Beta 1
Chromosome: CHR1: 169075946 -169101960
Locus: 1q24.2
NRG1 Gene Summary
The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
Gene Name: Neuregulin 1
Chromosome: CHR8: 31497267 -32600770
Locus: 8p12
Gene Diseases
The ATP1B1 NRG1 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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