ATP11B-CARS Fusion FISH Probe
The ATP11B-CARS Fusion FISH Probe is used to confirm a fusion of the ATP11B and CARS genes. The fusion of the ATP11B and CARS genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATP11B-CARS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-RERE | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-REOR | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-REGO | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-REGR | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-REAQ | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-ORRE | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-OROR | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-ORGO | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-GORE | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-GOOR | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-GOGO | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-GOGR | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-GRRE | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-GROR | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-GRGO | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-GRGR | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-AQRE | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-AQOR | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-AQGO | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-AQGR | 20 (40 μL) | 200 μL |
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| ATP11B-CARS-20-AQAQ | 20 (40 μL) | 200 μL |
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CARS Gene Summary
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Gene Name: Cysteinyl-tRNA Synthetase
Chromosome: CHR11: 3022151 -3078681
Locus: 11p15.4
ATP11B Gene Summary
P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM, Feb 2005]
Gene Name: ATPase Phospholipid Transporting 11B (putative)
Chromosome: CHR3: 182511290 -182639421
Locus: 3q26.33
Gene Diseases
The ATP11B CARS Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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