ATM-CARD18 Fusion FISH Probe
The ATM-CARD18 Fusion FISH Probe is used to confirm a fusion of the ATM and CARD18 genes. The fusion of the ATM and CARD18 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATM-CARD18-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-RERE | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-REOR | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-REGO | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-REGR | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-REAQ | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-ORRE | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-OROR | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-ORGO | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-GORE | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-GOOR | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-GOGO | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-GOGR | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-GRRE | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-GROR | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-GRGO | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-GRGR | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-AQRE | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-AQOR | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-AQGO | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-AQGR | 20 (40 μL) | 200 μL |
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| ATM-CARD18-20-AQAQ | 20 (40 μL) | 200 μL |
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ATM Gene Summary
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
Gene Name: ATM Serine/threonine Kinase
Chromosome: CHR11: 108093558 -108239826
Locus: 11q22.3
CARD18 Gene Summary
The Caspase Recruitment Domain Family Member 18 (CARD18) gene is located on chr11 :105008447-105010461 at 11q22.3.
Gene Name: Caspase Recruitment Domain Family Member 18
Chromosome: CHR11: 105008447 -105010461
Locus: 11q22.3
Gene Diseases
The ATM CARD18 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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