ATG5-SYNJ2 Fusion FISH Probe
The ATG5-SYNJ2 Fusion FISH Probe is used to confirm a fusion of the ATG5 and SYNJ2 genes. The fusion of the ATG5 and SYNJ2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATG5-SYNJ2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-RERE | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-REOR | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-REGO | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-REGR | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-REAQ | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-ORRE | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-OROR | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-ORGO | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-GORE | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-GOOR | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-GOGO | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-GOGR | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-GRRE | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-GROR | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-GRGO | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-GRGR | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-AQRE | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-AQOR | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-AQGO | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-AQGR | 20 (40 μL) | 200 μL |
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| ATG5-SYNJ2-20-AQAQ | 20 (40 μL) | 200 μL |
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SYNJ2 Gene Summary
The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Name: Synaptojanin 2
Chromosome: CHR6: 158402887 -158520207
Locus: 6q25.3
ATG5 Gene Summary
The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Gene Name: Autophagy Related 5
Chromosome: CHR6: 106632351 -106773695
Locus: 6q21
Gene Diseases
The ATG5 SYNJ2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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