ATG4D-UHRF1 Fusion FISH Probe
The ATG4D-UHRF1 Fusion FISH Probe is used to confirm a fusion of the ATG4D and UHRF1 genes. The fusion of the ATG4D and UHRF1 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATG4D-UHRF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-RERE | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-REOR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-REGO | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-REGR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-REAQ | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-ORRE | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-OROR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-ORGO | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GORE | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GOOR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GOGO | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GOGR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GRRE | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GROR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GRGO | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GRGR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-AQRE | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-AQOR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-AQGO | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-AQGR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-AQAQ | 20 (40 μL) | 200 μL |
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UHRF1 Gene Summary
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]
Gene Name: Ubiquitin Like With PHD And Ring Finger Domains 1
Chromosome: CHR19: 4909509 -4962165
Locus: 19p13.3
ATG4D Gene Summary
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: Autophagy Related 4D Cysteine Peptidase
Chromosome: CHR19: 10654646 -10664094
Locus: 19p13.2
Gene Diseases
The ATG4D UHRF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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