ATG4C-LEPR Fusion FISH Probe
The ATG4C-LEPR Fusion FISH Probe is used to confirm a fusion of the ATG4C and LEPR genes. The fusion of the ATG4C and LEPR genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATG4C-LEPR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-RERE | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-REOR | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-REGO | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-REGR | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-REAQ | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-ORRE | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-OROR | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-ORGO | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-GORE | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-GOOR | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-GOGO | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-GOGR | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-GRRE | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-GROR | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-GRGO | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-GRGR | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-AQRE | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-AQOR | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-AQGO | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-AQGR | 20 (40 μL) | 200 μL |
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| ATG4C-LEPR-20-AQAQ | 20 (40 μL) | 200 μL |
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LEPR Gene Summary
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]
Gene Name: Leptin Receptor
Chromosome: CHR1: 65886334 -66103176
Locus: 1p31.3
ATG4C Gene Summary
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Autophagy Related 4C Cysteine Peptidase
Chromosome: CHR1: 63249776 -63330941
Locus: 1p31.3
Gene Diseases
The ATG4C LEPR Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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