ATF6-VCL Fusion FISH Probe
The ATF6-VCL Fusion FISH Probe is used to confirm a fusion of the ATF6 and VCL genes. The fusion of the ATF6 and VCL genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATF6-VCL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-RERE | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-REOR | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-REGO | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-REGR | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-REAQ | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-ORRE | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-OROR | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-ORGO | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-GORE | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-GOOR | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-GOGO | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-GOGR | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-GRRE | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-GROR | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-GRGO | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-GRGR | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-AQRE | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-AQOR | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-AQGO | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-AQGR | 20 (40 μL) | 200 μL |
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| ATF6-VCL-20-AQAQ | 20 (40 μL) | 200 μL |
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VCL Gene Summary
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Vinculin
Chromosome: CHR10: 75757871 -75879914
Locus: 10q22.2
ATF6 Gene Summary
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
Gene Name: Activating Transcription Factor 6
Chromosome: CHR1: 161736033 -161933860
Locus: 1q23.3
Gene Diseases
The ATF6 VCL Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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