ATF2-SOS2 Fusion FISH Probe
The ATF2-SOS2 Fusion FISH Probe is used to confirm a fusion of the ATF2 and SOS2 genes. The fusion of the ATF2 and SOS2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATF2-SOS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-RERE | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-REOR | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-REGO | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-REGR | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-REAQ | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-ORRE | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-OROR | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-ORGO | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-GORE | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-GOOR | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-GOGO | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-GOGR | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-GRRE | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-GROR | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-GRGO | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-GRGR | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-AQRE | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-AQOR | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-AQGO | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-AQGR | 20 (40 μL) | 200 μL |
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| ATF2-SOS2-20-AQAQ | 20 (40 μL) | 200 μL |
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ATF2 Gene Summary
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]
Gene Name: Activating Transcription Factor 2
Chromosome: CHR2: 175939005 -176032897
Locus: 2q31.1
SOS2 Gene Summary
This gene encodes a regulatory protein that is involved in the positive regulation of ras proteins. Mutations in this gene are associated with Noonan Syndrome-9. [provided by RefSeq, Jul 2016]
Gene Name: SOS Ras/Rho Guanine Nucleotide Exchange Factor 2
Chromosome: CHR14: 50583845 -50698099
Locus: 14q21.3
Gene Diseases
The ATF2 SOS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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