ATF1-GRIP1 Fusion FISH Probe
The ATF1-GRIP1 Fusion FISH Probe is used to confirm a fusion of the ATF1 and GRIP1 genes. The fusion of the ATF1 and GRIP1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATF1-GRIP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-RERE | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-REOR | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-REGO | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-REGR | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-REAQ | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-ORRE | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-OROR | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-ORGO | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-GORE | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-GOOR | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-GOGO | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-GOGR | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-GRRE | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-GROR | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-GRGO | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-GRGR | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-AQRE | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-AQOR | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-AQGO | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-AQGR | 20 (40 μL) | 200 μL |
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| ATF1-GRIP1-20-AQAQ | 20 (40 μL) | 200 μL |
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ATF1 Gene Summary
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]
Gene Name: Activating Transcription Factor 1
Chromosome: CHR12: 51157788 -51214943
Locus: 12q13.12
GRIP1 Gene Summary
This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
Gene Name: Glutamate Receptor Interacting Protein 1
Chromosome: CHR12: 66741210 -67072925
Locus: 12q14.3
Gene Diseases
The ATF1 GRIP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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